FComEx: Loratadine (PC000903)

Record Information

Version

1.0

Creation date

2015-10-09 22:33:18 UTC

Update date

2017-01-19 02:36:40 UTC

FoodComEx ID

PC000903

FoodDB Record

FDB023577

Chemical Information

Name

Loratadine

Description

desloratadine is available off the shelf in Canada); Loratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not normally cause drowsiness because it does not readily enter the central nervous system; An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake; Loratadine is a drug used to treat allergies. It is marketed by Schering-Plough under several trade names such as Claritin, Clarityn or Claratyne depending on the market, by Lek as Lomilan and by Wyeth as Alavert. It is also available as a generic; Loratadine is a drug used to treat allergies. It is marketed by Schering-Plough under several trade names such as Claritin, Clarityn or Claratyne depending on the market, by Lek as Lomilan and by Wyeth as Alavert. It is also available as a generic. Its active metabolite, desloratadine, is also on the market, though loratadine itself is the only drug of its class available over the counter (at least in the U.S. as of 2005. Loratadine is available off the shelf in the UK [HMDB]

CAS Number

79794-75-5

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Synonym	Source
Alavert	hmdb
Amantadine	hmdb
Anhissen	hmdb
Bonalerg	hmdb
Claritin	Kegg
Claritine	hmdb
Clarityn	hmdb
Clarityne	hmdb
Cronopen	hmdb
Flonidan	hmdb
Fristamin	hmdb
Histaloran	hmdb
Klaritin	hmdb
Lertamine	hmdb
Lisino	hmdb
Loracert	hmdb
Loradex	hmdb
Loranox	hmdb
Lorastine	hmdb
Loratadine	hmdb
Loratidine	hmdb

Chemical Formula

C22H23ClN2O2

IUPAC name

ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate

InChI Identifier

InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI Key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Isomeric SMILES

CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2

Average Molecular Weight

382.883

Monoisotopic Molecular Weight

382.144805697

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzocycloheptapyridines. These are aromatic compounds containing a benzene ring and a pyridine ring fused to a seven membered carbocycle.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzocycloheptapyridines

Sub Class

Not Available

Direct Parent

Benzocycloheptapyridines

Alternative Parents