FComEx: N-Methylnicotinamide (PC000718)

Record Information

Version

1.0

Creation date

2015-10-09 22:32:12 UTC

Update date

2017-01-19 02:36:34 UTC

FoodComEx ID

PC000718

FoodDB Record

FDB023115

Chemical Information

Name

N-Methylnicotinamide

Description

N-methylnicotinamide is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-methylnicotinamide indicates niacin deficiency. (PMID: 16207585). In patients with liver cirrhosis nicotinamide methylation is increased leading to a rise in urinary N-methylnicotinamide. The hyperfunction of this methylating pathway might play a protective role against the toxic effect of intracellular accumulation of nicotinamide deriving from the catabolic state of cirrhosis. N-methylnicotinamide is known to inhibit choline transport and reduce choline clearance out of the brain. [HMDB]

CAS Number

114-33-0

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
3-(Methylcarbamoyl)pyridine	hmdb
3-(N-Methylcarbamoyl)pyridine	hmdb
N -Methyl nicotineamide	hmdb
N-Methyl nicotineamide	ChEBI
N-Methyl-3-pyridinecarboxamide	hmdb
N-methylnicotinamide	hmdb
N-Methylpyridine-3-carboxamide	ChEBI
Nicotinate methylamide	Generator
Nicotinic acid methylamide	hmdb

Chemical Formula

C7H8N2O

IUPAC name

N-methylpyridine-3-carboxamide

InChI Identifier

InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10)

InChI Key

ZYVXHFWBYUDDBM-UHFFFAOYSA-N

Isomeric SMILES

CNC(=O)C1=CN=CC=C1

Average Molecular Weight

136.1512

Monoisotopic Molecular Weight

136.063662888

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyridines and derivatives

Sub Class

Pyridinecarboxylic acids and derivatives

Direct Parent

Nicotinamides

Alternative Parents