FComEx: Frusemide (PC000564)

Record Information

Version

1.0

Creation date

2015-10-09 22:31:19 UTC

Update date

2017-01-19 02:36:28 UTC

FoodComEx ID

PC000564

FoodDB Record

FDB000956

Chemical Information

Name

Frusemide

Description

Potential contaminant in cow's milk arising from its use in dairy cattle for the treatment of physiological parturient edema Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of alpha6 beta2 gamma2 receptors at microM concentrations, but not alpha1 beta2 gamma2 receptors. During development, the alpha6 beta2 gamma2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to furosemide.; An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.; Furosemide (INN) or frusemide (former BAN) is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix. It has also been used to prevent thoroughbred and standardbred race horses from bleeding through the nose during races.; Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Aventis Pharma under the brand name Lasix. It has also been used to prevent thoroughbred race horses from bleeding through the nose during races.; Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.

CAS Number

54-31-9

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
2-Furfurylamino-4-chloro-5-sulfamoylbenzoate	Generator
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid	biospider
2-Furfurylamino-4-chloro-5-sulphamoylbenzoate	Generator
2-Furfurylamino-4-chloro-5-sulphamoylbenzoic acid	Generator
4-chloro-5-Sulfamoyl-N-furfuryl-anthranilate	Generator
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid	biospider
4-chloro-5-Sulphamoyl-N-furfuryl-anthranilate	Generator
4-chloro-5-Sulphamoyl-N-furfuryl-anthranilic acid	Generator
4-chloro-N-(2-Furylmethyl)-5-sulfamoylanthranilate	Generator
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid	biospider
4-chloro-N-(2-Furylmethyl)-5-sulphamoylanthranilate	Generator
4-chloro-N-(2-Furylmethyl)-5-sulphamoylanthranilic acid	Generator
4-chloro-N-Furfuryl-5-sulfamoylanthranilate	Generator
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid	db_source
4-chloro-N-Furfuryl-5-sulphamoylanthranilate	Generator
4-chloro-N-Furfuryl-5-sulphamoylanthranilic acid	Generator
5-(Aminosulfonyl)-4-chloro-2-[2-(furanylmethyl)amino]benzoic acid, 9CI	db_source
Acetic acid potassium salt	HMDB
Aisemide	HMDB
Aldalix	biospider
Aldic	biospider
Aluzine	biospider
Anfuramaide	biospider
Anthranilic acid, 4-chloro-N-furfuryl-5-sulfamoyl-	biospider
Apo-frusemide	biospider
Apo-furosemide	biospider
Aquarid	biospider
Aquasin	biospider
Arasemide	biospider
Beronald	HMDB
Bio-furosemide	biospider
Bioretic	biospider
Cetasix	biospider
Depix	biospider
Desal	biospider
Desdemin	HMDB
Dirine	biospider
Disal	HMDB
Discoid	HMDB
Disemide	biospider
Diural	HMDB
Diurapid	db_source
Diuretic salt	HMDB
Diurin	biospider
Diurolasa	biospider
Diusemide	biospider
Diusil	biospider
Diuzol	biospider
Dom-furosemide	biospider
Dranex	biospider
Dryptal	db_source
Durafurid	HMDB
Edemid	biospider
Edenol	biospider
Eliur	biospider
Endural	biospider
Errolon	HMDB
Eutensin	HMDB
Farsix	biospider
Fluidrol	biospider
Fluss	biospider
Franyl	biospider
Froop	db_source
Frumax	db_source
Frumex	biospider
Frumide	biospider
Frumil	HMDB
Frusedan	biospider
Frusema	biospider
Frusemid	biospider
Frusemide	biospider
Frusemide, BAN	db_source
Frusemin	biospider
Frusenex	biospider
Frusetic	HMDB
Frusid	db_source
Frusol	db_source
Fulsix	HMDB
Fuluvamide	HMDB
Fuluvamine	biospider
Furanthril	biospider
Furanthryl	biospider
Furantril	biospider
Furanturil	biospider
Furesis	HMDB
Furetic	biospider
Furex	biospider
Furfan	biospider
Furix	biospider
Furmid	biospider
Furo-basan	biospider
Furo-puren	HMDB
Furobeta	biospider
Furocot	biospider
Furodiurol	biospider
Furodrix	biospider
Furomen	biospider
Furomex	biospider
Furomide m.d.	biospider
Furorese	biospider
Furosan	biospider
Furose	biospider
Furosedon	HMDB
Furosemid	biospider
Furosemida	biospider
Furosemide "mita"	biospider
Furosemide 40mg	biospider
Furosemide special	biospider
Furosemide(usan)	biospider
Furosemidu	biospider
Furosemidum	biospider
Furosemix	biospider
Furoside	biospider
Furosifar	biospider
Furosix	biospider
Furoter	biospider
Furovite	biospider
Fursemid	biospider
Fursemida	biospider
Fursemide	db_source
Fursol	biospider
Fusid	biospider
Fusidic acid	biospider
Golan	biospider
Hissuflux	biospider
Hydrex	biospider
Hydro	biospider
hydro-Rapid	HMDB
Hydroled	biospider
Impugan	HMDB
Jenafusid	biospider
Katlex	HMDB
Kofuzon	biospider
Kolkin	biospider
Kutrix	biospider
Lasemid	biospider
Lasex	biospider
Lasiletten	biospider
Lasilix	HMDB
Lasix	db_source
Lasix retard	biospider
Lasix special	biospider
Laxur	biospider
Lazix	biospider
Less diur	biospider
Liside	biospider
Logirene	biospider
Lowpston	HMDB
Lowpstron	biospider
Luscek	biospider
Macasirool	HMDB
Marsemide	biospider
Mirfat	HMDB
MITA	biospider
Moilarorin	biospider
Nadis	biospider
Nelsix	biospider
Neo-renal	biospider
Nephron	biospider
Nicorol	HMDB
Novosemide	biospider
Octan draselny	HMDB
Odemase	HMDB
Odemex	biospider
Oedemex	HMDB
Osyrol	biospider
PMS-furosemide	biospider
Polysquall a	biospider
Prefemin	biospider
Profemin	HMDB
Promedes	biospider
Promide	biospider
Protargen	biospider
Puresis	biospider
Radisemide	biospider
Radonna	biospider
Radouna	biospider
Retep	biospider
Rosemide	HMDB
Rosis	biospider
Rusyde	db_source
Sal diureticum	HMDB
Salinex	biospider
Salix	biospider
Salurex	biospider
Salurid	biospider
Seguril	biospider
Selectofur	biospider
Sigasalur	biospider
Spirofur	biospider
Synephron	biospider
Tenkafruse	db_source
Transit	biospider
Trofurit	HMDB
Uremide	biospider
Uresix	biospider
Urex	HMDB
Urex-m	biospider
Urian	biospider
Uridon	biospider
Uritol	biospider
Urosemide	biospider
Vesix	biospider
Yidoli	biospider
Zafimida	biospider

Chemical Formula

C12H11ClN2O5S

IUPAC name

4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid

InChI Identifier

InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI Key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Isomeric SMILES

NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O

Average Molecular Weight

330.744

Monoisotopic Molecular Weight

330.007719869

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzenesulfonamides

Direct Parent

Aminobenzenesulfonamides

Alternative Parents