FComEx: Hydrochlorothiazide (PC000559)

Record Information

Version

1.0

Creation date

2015-10-09 22:31:18 UTC

Update date

2017-01-19 02:36:28 UTC

FoodComEx ID

PC000559

FoodDB Record

FDB022745

Chemical Information

Name

Hydrochlorothiazide

Description

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. -- Pubchem Hydrochlorothiazide (Apo-Hydro, Aquazide H, Microzide, Oretic), sometimes abbreviated HCT, HCTZ, or HZT is a popular diuretic drug that acts by inhibiting the kidney's ability to retain water. This reduces the volume of the blood, decreasing peripheral vascular resistance. Chlorothiazide, a carbonic anhydrase inhibitor. --Wikipedia [HMDB]

CAS Number

58-93-5

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
3,4-Dihydrochlorothiazide	hmdb
Acuretic	hmdb
Aldactazide	hmdb
Aldoril	hmdb
Apresazide	hmdb
Aquarills	hmdb
Aquarius	hmdb
Bremil	hmdb
Caplaril	hmdb
Capozide	hmdb
Chlorosulthiadil	hmdb
Chlorothiazide	hmdb
Chlorsulfonamidodihydrobenzothiadiazine dioxide	hmdb
Chlorzide	hmdb
Cidrex	hmdb
Dichlorosal	hmdb
Dichlotiazid	hmdb
Dichlotride	hmdb
Diclotride	hmdb
Dihydrochlorothiazid	hmdb
Dihydrochlorothiazide	hmdb
Dihydrochlorothiazidum	hmdb
Dihydrochlorurit	hmdb
Dihydrochlorurite	hmdb
Dihydroxychlorothiazidum	hmdb
Direma	hmdb
Disalunil	hmdb
Diuril	hmdb
Drenol	hmdb
Dyazide	hmdb
Esidrex	hmdb
Esidrix	hmdb
Esimil	hmdb
Fluvin	hmdb
HCTZ	hmdb
HCZ	hmdb
Hidril	hmdb
Hidrochlortiazid	hmdb
Hidroclorotiazida	ChEBI
Hidroronol	hmdb
Hidrotiazida	hmdb
Hydril	hmdb
Hydro-Aquil	hmdb
Hydro-D	hmdb
Hydro-Diuril	hmdb
Hydrochloro Thiazide	hmdb
Hydrochlorothiazid	hmdb
Hydrochlorothiazide	hmdb
Hydrochlorothiazide Intensol	hmdb
Hydrochlorothiazidum	ChEBI
Hydrochlorthiazide	hmdb
Hydrodiuretic	hmdb
Hydrodiuril	hmdb
Hydropres	hmdb
Hydrosaluric	hmdb
Hydrothide	hmdb
Hydrozide	hmdb
Hypothiazid	hmdb
Hypothiazide	hmdb
Hyzaar	hmdb
Idrotiazide	hmdb
Inderide	hmdb
Ivaugan	hmdb
Jen-Diril	hmdb
Lopressor HCT	hmdb
Lotensin HCT	hmdb
Maschitt	hmdb
Maxzide	hmdb
Megadiuril	hmdb
Microzide	hmdb
Moduretic	hmdb
Nefrix	hmdb
Neo-codema	hmdb
Neoflumen	hmdb
Newtolide	hmdb
Oretic	hmdb
Panurin	hmdb
Prinzide	hmdb
Ro-hydrazide	hmdb
Ser-Ap-Es	hmdb
Servithiazid	hmdb
Thiaretic	hmdb
Thiuretic	hmdb
Thlaretic	hmdb
Timolide	hmdb
Unipres	hmdb
Urodiazin	hmdb
Vaseretic	hmdb
Vetidrex	hmdb
Ziac	hmdb
Zide	hmdb

Chemical Formula

C7H8ClN3O4S2

IUPAC name

6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

InChI Identifier

InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChI Key

JZUFKLXOESDKRF-UHFFFAOYSA-N

Isomeric SMILES

NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1

Average Molecular Weight

297.739

Monoisotopic Molecular Weight

296.964474846

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Thiadiazines

Sub Class

Benzothiadiazines

Direct Parent

1,2,4-benzothiadiazine-1,1-dioxides

Alternative Parents