Record Information |
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Version | 1.0 |
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Creation date | 2015-10-09 22:31:18 UTC |
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Update date | 2017-01-19 02:36:28 UTC |
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FoodComEx ID | PC000557 |
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FoodDB Record | FDB022742 |
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Chemical Information |
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Name | Atenolol |
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Description | Atenolol is a so-called beta1-selective (or 'cardioselective') drug. That means that it exerts greater blocking activity on myocardial beta1-receptors than on beta2 ones in the lung. The beta2 receptors are responsible to keep the bronchial system open. If these receptors are blocked, bronchospasm with serious lack of oxygen in the body can result. However, due to its cardioselective properties, the risk of bronchospastic reactions if using atenolol is reduced compared to nonselective drugs as propranolol. Nonetheless, this reaction may also be encountered with atenolol, particularly with high doses. Extreme caution should be exerted if atenolol is given to asthma patients, who are particularly at risk; the dose should be as low as possible. If an asthma attack occurs, the inhalation of a beta2-mimetic antiasthmatic, such as hexoprenalin or salbutamol, will usually suppress the symptoms.; Atenolol (trade name Tenormin) can be used to treat cardiovascular diseases such as hypertension, coronary heart disease, arrhythmias, and treatment of myocardial infarction after the acute event. Patients with compensated congestive heart failure may be treated with atenolol as a co medication (usually together with an ACE inhibitor, a diuretic and a digitalis-glycoside, if indicated). In patients with congestive heart failure, it reduces the need for and the consumption of oxygen of the heart muscle. It is very important to start with low doses, as atenolol reduces also the muscular power of the heart, which is an undesired effect in congestive heart failure. [HMDB] |
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CAS Number | 29122-68-7 |
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Structure | |
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Synonyms | Synonym | Source |
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1-P-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol | ChEBI | 2-(P-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide | ChEBI | 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide | ChEBI | Aircrit | hmdb | Alinor | hmdb | Altol | hmdb | Anselol | hmdb | Antipressan | hmdb | Apo-Atenolol | hmdb | Atcardil | hmdb | Atecard | hmdb | Atehexal | hmdb | Atenblock | hmdb | Atendol | hmdb | Atenet | hmdb | Ateni | hmdb | Atenil | hmdb | Atenol 1A pharma | hmdb | Atenol acis | hmdb | Atenol AL | hmdb | Atenol Atid | hmdb | Atenol Cophar | hmdb | Atenol ct | hmdb | Atenol Fecofar | hmdb | Atenol Gador | hmdb | Atenol Genericon | hmdb | Atenol GNR | hmdb | Atenol Heumann | hmdb | Atenol MSD | hmdb | Atenol NM Pharma | hmdb | Atenol Nordic | hmdb | Atenol PB | hmdb | Atenol Quesada | hmdb | Atenol Stada | hmdb | Atenol Tika | hmdb | Atenol Trom | hmdb | Atenol von ct | hmdb | Atenol-Mepha | hmdb | Atenol-ratiopharm | hmdb | Atenol-Wolff | hmdb | Atenolin | hmdb | Atenolol (JAN/USP) | hmdb | Atenolol [USAN:BAN:INN:JAN] | hmdb | Atenololum | ChEBI | Atenololum [INN-Latin] | hmdb | Atenomel | hmdb | Atereal | hmdb | Aterol | hmdb | Betablok | hmdb | Betacard | hmdb | Betasyn | hmdb | Betatop Ge | hmdb | Blocotenol | hmdb | Blokium | hmdb | Cardaxen | hmdb | Cardiopress | hmdb | Corotenol | hmdb | Cuxanorm | hmdb | Duraatenolol | hmdb | duratenol | hmdb | Evitocor | hmdb | Farnormin | hmdb | Felo-Bits | hmdb | Hipres | hmdb | Hypoten | hmdb | Ibinolo | hmdb | Internolol | hmdb | Jenatenol | hmdb | Juvental | hmdb | Lo-ten | hmdb | Loten | hmdb | Lotenal | hmdb | Myocord | hmdb | Normalol | hmdb | Normiten | hmdb | Noten | hmdb | Oraday | hmdb | Ormidol | hmdb | Panapres | hmdb | Plenacor | hmdb | Premorine | hmdb | Prenolol | hmdb | Prenormine | hmdb | Prinorm | hmdb | Scheinpharm Atenol | hmdb | Seles beta | hmdb | Selobloc | hmdb | Serten | hmdb | Servitenol | hmdb | Stermin | hmdb | Tenidon | hmdb | Tenobloc | hmdb | Tenoblock | hmdb | Tenolol | hmdb | Tenoprin | hmdb | Tenoretic | hmdb | Tenormin | hmdb | Tenormin (TN) | hmdb | Tenormine | hmdb | Tenormine [French] | hmdb | Tensimin | hmdb | Tredol | hmdb | Unibloc | hmdb | Uniloc | hmdb | Vascoten | hmdb | Vericordin | hmdb | Wesipin | hmdb | Xaten | hmdb |
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Chemical Formula | C14H22N2O3 |
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IUPAC name | 2-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide |
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InChI Identifier | InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18) |
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InChI Key | METKIMKYRPQLGS-UHFFFAOYSA-N |
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Isomeric SMILES | CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 |
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Average Molecular Weight | 266.3361 |
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Monoisotopic Molecular Weight | 266.16304258 |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Benzene and substituted derivatives |
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Sub Class | Phenylacetamides |
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Direct Parent | Phenylacetamides |
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Alternative Parents | |
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Substituents | - Phenylacetamide
- Phenoxy compound
- Phenol ether
- Alkyl aryl ether
- 1,2-aminoalcohol
- Amino acid or derivatives
- Carboxamide group
- Secondary alcohol
- Primary carboxylic acid amide
- Carboxylic acid derivative
- Secondary amine
- Secondary aliphatic amine
- Ether
- Organic nitrogen compound
- Organonitrogen compound
- Organooxygen compound
- Hydrocarbon derivative
- Organic oxide
- Carbonyl group
- Organopnictogen compound
- Amine
- Organic oxygen compound
- Alcohol
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Physico-Chemical Properties - Experimental |
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Property | Value | Reference |
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Experimental logP | Not Available | |
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Experimental Water Solubility | Not Available | |
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Melting Point | Not Available | |
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Foods of Origin |
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Food | Content Range | Average | Reference |
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Food | | | Reference |
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Production Data |
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Production Method | commercial |
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Production Method Reference | Not Available |
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Production Method Reference File | Not Available |
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Quantity Available | Production upon request, up to 500 mg |
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Delivery Time | Not Available |
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Storage Form | solid |
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Storage Conditions | -80°C |
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Stability | Not Available |
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Purity | Not Available |
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Spectra |
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Spectral Data Upon Request | Not Available |
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Provider Information |
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Commercial Vendors |
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AKSci | E636 |
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AKSci | J10009 |
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AKSci | J40155 |
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AKSci | J94324 |
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AKSci | HMDB0001924 |
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Cayman Chemical | 17250 |
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MetaSci | HMDB0001924 |
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Toronto Research Chemicals | A790075 |
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