Record Information
Version1.0
Creation date2015-10-09 22:31:18 UTC
Update date2017-01-19 02:36:28 UTC
FoodComEx IDPC000557
FoodDB RecordFDB022742
Chemical Information
NameAtenolol
DescriptionAtenolol is a so-called beta1-selective (or 'cardioselective') drug. That means that it exerts greater blocking activity on myocardial beta1-receptors than on beta2 ones in the lung. The beta2 receptors are responsible to keep the bronchial system open. If these receptors are blocked, bronchospasm with serious lack of oxygen in the body can result. However, due to its cardioselective properties, the risk of bronchospastic reactions if using atenolol is reduced compared to nonselective drugs as propranolol. Nonetheless, this reaction may also be encountered with atenolol, particularly with high doses. Extreme caution should be exerted if atenolol is given to asthma patients, who are particularly at risk; the dose should be as low as possible. If an asthma attack occurs, the inhalation of a beta2-mimetic antiasthmatic, such as hexoprenalin or salbutamol, will usually suppress the symptoms.; Atenolol (trade name Tenormin) can be used to treat cardiovascular diseases such as hypertension, coronary heart disease, arrhythmias, and treatment of myocardial infarction after the acute event. Patients with compensated congestive heart failure may be treated with atenolol as a co medication (usually together with an ACE inhibitor, a diuretic and a digitalis-glycoside, if indicated). In patients with congestive heart failure, it reduces the need for and the consumption of oxygen of the heart muscle. It is very important to start with low doses, as atenolol reduces also the muscular power of the heart, which is an undesired effect in congestive heart failure. [HMDB]
CAS Number29122-68-7
Structure
Thumb
Synonyms
SynonymSource
1-P-Carbamoylmethylphenoxy-3-isopropylamino-2-propanolChEBI
2-(P-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamideChEBI
4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamideChEBI
Aircrithmdb
Alinorhmdb
Altolhmdb
Anselolhmdb
Antipressanhmdb
Apo-Atenololhmdb
Atcardilhmdb
Atecardhmdb
Atehexalhmdb
Atenblockhmdb
Atendolhmdb
Atenethmdb
Atenihmdb
Atenilhmdb
Atenol 1A pharmahmdb
Atenol acishmdb
Atenol ALhmdb
Atenol Atidhmdb
Atenol Copharhmdb
Atenol cthmdb
Atenol Fecofarhmdb
Atenol Gadorhmdb
Atenol Genericonhmdb
Atenol GNRhmdb
Atenol Heumannhmdb
Atenol MSDhmdb
Atenol NM Pharmahmdb
Atenol Nordichmdb
Atenol PBhmdb
Atenol Quesadahmdb
Atenol Stadahmdb
Atenol Tikahmdb
Atenol Tromhmdb
Atenol von cthmdb
Atenol-Mephahmdb
Atenol-ratiopharmhmdb
Atenol-Wolffhmdb
Atenolinhmdb
Atenolol (JAN/USP)hmdb
Atenolol [USAN:BAN:INN:JAN]hmdb
AtenololumChEBI
Atenololum [INN-Latin]hmdb
Atenomelhmdb
Aterealhmdb
Aterolhmdb
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Cardaxenhmdb
Cardiopresshmdb
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duratenolhmdb
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Tenidonhmdb
Tenoblochmdb
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Tenololhmdb
Tenoprinhmdb
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Tenorminhmdb
Tenormin (TN)hmdb
Tenorminehmdb
Tenormine [French]hmdb
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Tredolhmdb
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Chemical FormulaC14H22N2O3
IUPAC name2-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
InChI IdentifierInChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
InChI KeyMETKIMKYRPQLGS-UHFFFAOYSA-N
Isomeric SMILESCC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1
Average Molecular Weight266.3361
Monoisotopic Molecular Weight266.16304258
Chemical Taxonomy
ClassificationNot classified
Physico-Chemical Properties - Experimental
PropertyValueReference
Experimental logPNot Available
Experimental Water SolubilityNot Available
Melting PointNot Available
Foods of Origin
FoodContent Range AverageReference
FoodReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 500 mg
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectra
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez Fresnovazquezf@ualberta.ca
Commercial Vendors
AKSci E636
AKSci J10009
AKSci J40155
AKSci J94324
AKSci HMDB0001924
Cayman Chemical 17250
MetaSci HMDB0001924
Toronto Research Chemicals A790075