FComEx: Salicylic acid (PC000529)

Record Information

Version

1.0

Creation date

2015-10-09 22:31:10 UTC

Update date

2017-01-19 02:36:27 UTC

FoodComEx ID

PC000529

FoodDB Record

FDB000882

Chemical Information

Name

Salicylic acid

Description

Preservative, fungicide (superseded), prohibited in milk and wine Salicylic acid is a colorless, crystalline organic carboxylic acid. Salicylic acid is toxic if ingested in large quantities, but in small quantities is used as a food preservative and antiseptic in toothpaste. It is also the key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts. The carboxyl group (COOH) can react with alcohols, forming several useful esters. The name derives from the latin word for the willow tree (Salix), from whose bark it can be obtained.; --Wikipedia; Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic. Salicylic acid is found in many foods, some of which are sourdock, horned melon, sesame, and cloud ear fungus.

CAS Number

69-72-7

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Synonym	Source
2 Hydroxybenzoic Acid	biospider
2-Carboxyphenol	biospider
2-Hydroxybenzenecarboxylate	biospider
2-Hydroxybenzenecarboxylic acid	biospider
2-Hydroxybenzoate	biospider
2-HYDROXYBENZOIC ACID	ChEBI
54-21-7 (SODIUM SALT)	biospider
Acid, 2-Hydroxybenzoic	biospider
Acid, o-hydroxybenzoic	biospider
Acid, ortho-hydroxybenzoic	biospider
Acid, salicylic	biospider
Acido salicilico	biospider
Acidum salicylicum	biospider
Advanced pain relief callus removers	biospider
Advanced pain relief corn removers	biospider
Alpha/beta hydroxy acids (glycolic acid, salicylic acid)	biospider
Benzoic acid, 2-hydroxy-	biospider
Benzoic acid, 2-hydroxy- (9CI)	biospider
Benzoic acid, o-hydroxy-	biospider
Clear away wart remover	biospider
Compound w	biospider
Domerine	biospider
DR. scholl's callus removers	biospider
DR. scholl's corn removers	biospider
DR. scholl's wart remover kit	biospider
Duofil wart remover	biospider
Duofilm	biospider
Duoplant	biospider
Freezone	biospider
Ionil	biospider
Ionil plus	biospider
Ionil-plus	biospider
K 537	HMDB
K 557	HMDB
Keralyt	biospider
O hydroxybenzoic acid	biospider
O-carboxyphenol	biospider
O-hydroxybenzoate	biospider
O-hydroxybenzoic acid	biospider
Occlusal	biospider
Ortho hydroxybenzoic acid	biospider
Ortho-hydroxybenzoic acid	biospider
Orthohydroxybenzoic acid	biospider
Pernox	biospider
phenol derivative, 7	biospider
Phenol-2-carboxylate	biospider
Phenol-2-carboxylic acid	biospider
Psoriacid-s-stift	biospider
Retarder sax	biospider
Retarder w	biospider
Rutranex	biospider
SA	biospider
SAL	biospider
Salicyclic acid	biospider
Salicylate	biospider
Salicylic acid	db_source
Salicylic acid (6CI,8CI)	biospider
Salicylic acid (see also alpha hydroxy acids)	biospider
Salicylic acid [usan:jan]	biospider
Salicylic acid collodion	biospider
Salicylic acid soap	biospider
Salicylic acid, acs	biospider
Saligel	biospider
Salonil	biospider
SAX	biospider
Sebucare	biospider
Sebulex	biospider
Stri-dex	biospider
Trans-ver-sal	biospider
Verrugon	biospider

Chemical Formula

C7H6O3

IUPAC name

2-hydroxybenzoic acid

InChI Identifier

InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI Key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

Isomeric SMILES

OC(=O)C1=CC=CC=C1O

Average Molecular Weight

138.122

Monoisotopic Molecular Weight

138.031694053

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzoic acids and derivatives

Direct Parent

Salicylic acids

Alternative Parents

Substituents

Salicylic acid
Benzoic acid
Benzoyl
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Vinylogous acid
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

monohydroxybenzoic acid (CHEBI:16914 )

Physico-Chemical Properties - Experimental

Property	Value	Reference
Experimental logP	2.26	HANSCH,C ET AL. (1995)
Experimental Water Solubility	2.24 mg/mL at 25 oC	YALKOWSKY,SH & DANNENFELSER,RM (1992)
Melting Point	Mp 159°	DFC

Foods of Origin