Record Information
Creation date2015-10-09 22:30:49 UTC
Update date2017-01-19 02:36:25 UTC
FoodComEx IDPC000463
FoodDB RecordFDB021915
Chemical Information
DescriptionEndogenous sulfite is generated as a consequence of the body's normal processing of sulfur-containing amino acids. Sulfites occur as a consequence of fermentation and also occur naturally in a number of foods and beverages. As food additives, sulfiting agents were first used in 1664 and approved in the United States as long ago as the 1800s. Sulfite sensitivity occurs most often in asthmatic adults--predominantly women; it is uncommonly reported in preschool children. Adverse reactions to sulfites in nonasthmatics are extremely rare. Asthmatics who are steroid-dependent or who have a higher degree of airway hyperreactivity may be at greater risk of experiencing a reaction to sulfite-containing foods. Sulfite sensitivity reactions vary widely, ranging from no reaction to severe. The majority of reactions are mild. These manifestations may include dermatologic, respiratory, or gastrointestinal signs and symptoms. The precise mechanisms of the sensitivity responses have not been completely elucidated. Inhalation of sulfur dioxide (SO2) generated in the stomach following ingestion of sulfite-containing foods or beverages, a deficiency in a mitochondrial enzyme, and an IgE-mediated immune response have all been implicated. Exogenously supplied sulfite is detoxified by the enzyme sulfite oxidase. Sulfite oxidase (EC is 1 of 3 enzymes in humans that requires molybdenum as a cofactor. Sulfite oxidase deficiency is a rare autosomal inherited disease with severe neurological symptoms such as untreatable seizures, attenuated growth of the brain and mental retardation. It results from defects in the enzyme sulfite oxidase, which is responsible for the oxidation of sulfite to sulfate. This reaction is the final step in the degradation of sulfur containing metabolites including the amino acids cysteine and methionine. is a neurometabolic disease that results in severe developmental delay and premature death. The term isolated sulfite oxidase deficiency is used to define the deficiency caused by mutations in the sulfite oxidase gene. This differentiates it from another version of sulfite oxidase deficiency that is due to defects in the Moco biosynthetic pathway. Isolated sulfite oxidase deficiency is a rare but devastating neurologic disease that usually presents in early infancy with seizures and alterations in muscle tone. (PMID: 16234925, 16140720, 8586770) [HMDB]. Sulfite is found in many foods, some of which are sunflower, grapefruit/pummelo hybrid, passion fruit, and kelp.
CAS Number14265-45-3
Sulfite dianionhmdb
Sulfite ionhmdb
Sulfite ionshmdb
Sulfur trioxidehmdb
Sulfuric anhydridehmdb
Sulphite ionGenerator
Chemical FormulaO3S
IUPAC namesulfite
InChI IdentifierInChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2
Isomeric SMILES[O-]S([O-])=O
Average Molecular Weight80.063
Monoisotopic Molecular Weight79.956814556
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as non-metal sulfites. These are inorganic non-metallic compounds containing a sulfite as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal sulfites
Direct ParentNon-metal sulfites
Alternative Parents
  • Non-metal sulfite
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physico-Chemical Properties - Experimental
Experimental logPNot Available
Experimental Water SolubilityNot Available
Melting PointNot Available
Foods of Origin
FoodContent Range AverageReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 2 g
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez
Commercial Vendors
Not Available