FComEx: Aldosterone (PC000374)

Record Information

Version

1.0

Creation date

2015-10-09 22:30:18 UTC

Update date

2017-01-19 02:36:21 UTC

FoodComEx ID

PC000374

FoodDB Record

FDB021883

Chemical Information

Name

Aldosterone

Description

Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidney's collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. [HMDB]

CAS Number

52-39-1

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
(+)-Aldosterone	hmdb
(11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al	hmdb
(11beta)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al	hmdb
11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde	hmdb
11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al	hmdb
11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al	hmdb
11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al	hmdb
11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al	hmdb
11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al	hmdb
11beta,21-Dihydroxypregn-4-ene-3,18,20-trione	hmdb
18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione	hmdb
18-Oxocorticosterone	hmdb
Aldocorten	hmdb
Aldocortene	hmdb
Aldocortin	hmdb
aldosterone	hmdb
Aldosteronum	hmdb
d-Aldosterone	hmdb
delta-Aldosterone	hmdb
Electrocortin	hmdb
Elektrocortin	hmdb
Reichstein X	hmdb

Chemical Formula

C21H28O5

IUPAC name

(2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde

InChI Identifier

InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1

InChI Key

PQSUYGKTWSAVDQ-SRPWZAMTSA-N

Isomeric SMILES

C[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=O

Average Molecular Weight

360.444

Monoisotopic Molecular Weight

360.193674006

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Hydroxysteroids

Direct Parent

21-hydroxysteroids

Alternative Parents