Record Information
Version1.0
Creation date2015-10-09 22:30:01 UTC
Update date2017-01-19 02:36:20 UTC
FoodComEx IDPC000337
FoodDB RecordNot Available
Chemical Information
NameDeoxycorticosterone
DescriptionDeoxycorticosterone is a steroid or mineralocorticoid secreted by the zona fasiculata of the adrenal cortex. Deoxycorticsterone acts as a precursor to aldosterone. Deoxycorticosterone is not a major secretory hormone. It is produced from progesterone by 21beta-hydroxylase and is converted to corticosterone by 11beta-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Deoxycorticosterone stimulates the collecting tubules in the kidney to continue to excrete potassium in much the same way that aldosterone does. Deoxycorticosterone has about 1/20 of the sodium retaining power of aldosterone and about 1/5 the potassium excreting power of aldosterone [Wikipedia]. Deoxycorticosterone can be used to treat adrenal insufficiency. In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's disease. [HMDB]
CAS Number64-85-7
Structure
Thumb
Synonyms
SynonymSource
11-Dehydroxycorticosteronehmdb
11-deoxy-Corticosteronehmdb
11-Deoxycorticosteronehmdb
11-Desoxycorticosteronehmdb
21-Hydroxy-3,20-dioxopregn-4-enehmdb
21-Hydroxy-4-pregnene-3,20-dioneChEBI
21-Hydroxy-D4-pregnane-3,20-dionehmdb
21-Hydroxy-D4-pregnene-3,20-dionehmdb
21-hydroxy-Pregn-4-ene-3,20-dionehmdb
21-hydroxy-Progesteronehmdb
21-Hydroxypregn-4-ene-3,20-dionehmdb
21-Hydroxyprogesteronehmdb
4-Pregnen-21-ol-3,20-dionehmdb
Cortexonehmdb
D4-Pregnene-21-ol-3,20-dionehmdb
Deoxycortonehmdb
Desoxycorticosteronehmdb
Desoxycortonehmdb
DOChmdb
Docahmdb
Kendall's desoxy compound Bhmdb
Reichstein's substance Qhmdb
Chemical FormulaNot Available
IUPAC nameNot Available
InChI IdentifierInChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1
InChI KeyZESRJSPZRDMNHY-YFWFAHHUSA-N
Isomeric SMILES[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Average Molecular Weight330.4611
Monoisotopic Molecular Weight330.219494826
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 21-hydroxysteroid
  • Pregnane-skeleton
  • 20-oxosteroid
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • Oxosteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Alpha-hydroxy ketone
  • Cyclic ketone
  • Ketone
  • Organic oxygen compound
  • Organooxygen compound
  • Primary alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxide
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Physico-Chemical Properties - Experimental
PropertyValueReference
Experimental logPNot Available
Experimental Water SolubilityNot Available
Melting PointNot Available
Foods of Origin
FoodContent Range AverageReference
FoodReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 300 mg
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectra
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez Fresnovazquezf@ualberta.ca
Commercial Vendors
AKSci N730
Cayman Chemical 22916
Toronto Research Chemicals D232590