FComEx: Deoxycorticosterone (PC000337)

Record Information

Version

1.0

Creation date

2015-10-09 22:30:01 UTC

Update date

2017-01-19 02:36:20 UTC

FoodComEx ID

PC000337

FoodDB Record

Not Available

Chemical Information

Name

Deoxycorticosterone

Description

Deoxycorticosterone is a steroid or mineralocorticoid secreted by the zona fasiculata of the adrenal cortex. Deoxycorticsterone acts as a precursor to aldosterone. Deoxycorticosterone is not a major secretory hormone. It is produced from progesterone by 21beta-hydroxylase and is converted to corticosterone by 11beta-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Deoxycorticosterone stimulates the collecting tubules in the kidney to continue to excrete potassium in much the same way that aldosterone does. Deoxycorticosterone has about 1/20 of the sodium retaining power of aldosterone and about 1/5 the potassium excreting power of aldosterone [Wikipedia]. Deoxycorticosterone can be used to treat adrenal insufficiency. In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's disease. [HMDB]

CAS Number

64-85-7

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
11-Dehydroxycorticosterone	hmdb
11-deoxy-Corticosterone	hmdb
11-Deoxycorticosterone	hmdb
11-Desoxycorticosterone	hmdb
21-Hydroxy-3,20-dioxopregn-4-ene	hmdb
21-Hydroxy-4-pregnene-3,20-dione	ChEBI
21-Hydroxy-D4-pregnane-3,20-dione	hmdb
21-Hydroxy-D4-pregnene-3,20-dione	hmdb
21-hydroxy-Pregn-4-ene-3,20-dione	hmdb
21-hydroxy-Progesterone	hmdb
21-Hydroxypregn-4-ene-3,20-dione	hmdb
21-Hydroxyprogesterone	hmdb
4-Pregnen-21-ol-3,20-dione	hmdb
Cortexone	hmdb
D4-Pregnene-21-ol-3,20-dione	hmdb
Deoxycortone	hmdb
Desoxycorticosterone	hmdb
Desoxycortone	hmdb
DOC	hmdb
Doca	hmdb
Kendall's desoxy compound B	hmdb
Reichstein's substance Q	hmdb

Chemical Formula

Not Available

IUPAC name

Not Available

InChI Identifier

InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1

InChI Key

ZESRJSPZRDMNHY-YFWFAHHUSA-N

Isomeric SMILES

[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Average Molecular Weight

330.4611

Monoisotopic Molecular Weight

330.219494826

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Hydroxysteroids

Direct Parent

21-hydroxysteroids

Alternative Parents

Substituents

Progestogin-skeleton
21-hydroxysteroid
Pregnane-skeleton
20-oxosteroid
3-oxo-delta-4-steroid
3-oxosteroid
Oxosteroid
Delta-4-steroid
Cyclohexenone
Alpha-hydroxy ketone
Cyclic ketone
Ketone
Organic oxygen compound
Organooxygen compound
Primary alcohol
Carbonyl group
Hydrocarbon derivative
Alcohol
Organic oxide
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

3-oxo Delta(4)-steroid (CHEBI:16973 )
20-oxo steroid (CHEBI:16973 )
mineralocorticoid (CHEBI:16973 )
21-hydroxy steroid (CHEBI:16973 )
Pregnane and derivatives [Fig] (C03205 )
C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives (C03205 )
Mineralocorticoids (C03205 )
C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030087 )