FComEx: D-Mannitol (PC000323)

Record Information

Version

1.0

Creation date

2015-10-09 22:29:53 UTC

Update date

2017-01-19 02:36:20 UTC

FoodComEx ID

PC000323

FoodDB Record

FDB001982

Chemical Information

Name

D-Mannitol

Description

Permitted bulk sweetener for foods. Sweetening agent. Food additive, used as anticaking agent, lubricant, for stabiliser and thickener, and for other uses in food processing A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.; Chemically, mannitol is an alcohol and a sugar, or a polyol; Mannitol is a non-permeating molecule i.e. it cannot cross biological membranes.; Mannitol is a sugar alcohol, that is, it is derived from a sugar by reduction. Other sugar alcohols include xylitol and sorbitol. Aqueous solutions of mannitol are mildly acidic and sometimes such solutions are treated to raise the pH. Chemical Abstracts Registry Numbers for mannitol are 123897-58-5, 69-65-8 (D-Mannitol), 75398-80-0, 85085-15-0, and 87-78-5 (mannitol with unspecified stereochemistry).; Mannitol is an organic compound with the formula (C6H8(OH)6). This polyol is used as an osmotic diuretic agent and a weak renal vasodilator. It was originally isolated from the secretions of the flowering ash, called manna after their resemblance to the Biblical food, and is also be referred to as mannite and manna sugar.; Mannitol or hexan-1,2,3,4,5,6-hexol (C6H8(OH)6) is an osmotic diuretic agent and a weak renal vasodilator. It is a sorbitol isomer.; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic. For this, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate. D-Mannitol is found in many foods, some of which are agave, tronchuda cabbage, lupine, and apricot.

CAS Number

69-65-8

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Synonym	Source
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol	ChEBI
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol	ChEBI
1,2,3,4,5,6-Hexanehexol	HMDB
Cordycepate	biospider
Cordycepic acid	db_source
CPD without stereochemical designation	biospider
D-(-)-mannitol	biospider
D-mannite	biospider
Diosmol	HMDB
DL-mannitol	biospider
e 421	ChEBI
e-421	ChEBI
E421	db_source
Hexahydroxyhexane	HMDB
Hexanhexol	biospider
Invenex	biospider
Isotol	HMDB
Manicol	HMDB
Manita	db_source
Maniton s	biospider
Maniton-S	HMDB
Manna sugar	ChEBI
Mannazucker	HMDB
Mannazucker (german)	biospider
Mannidex	HMDB
Mannigen	HMDB
Mannistol	HMDB
Mannit	HMDB
Mannit p	biospider
Mannite	ChEBI
Mannitol	ChEBI
Mannitol (van)	biospider
Mannitol [usan]	biospider
MANNITOL 10%	biospider
MANNITOL 10% IN PLASTIC CONTAINER	biospider
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER	biospider
MANNITOL 15%	biospider
MANNITOL 15% IN PLASTIC CONTAINER	biospider
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%	biospider
MANNITOL 20%	biospider
MANNITOL 20% IN PLASTIC CONTAINER	biospider
MANNITOL 25%	biospider
MANNITOL 5%	biospider
MANNITOL 5% IN PLASTIC CONTAINER	biospider
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%	biospider
Mannogem 2080	biospider
Marine crystal	biospider
MTL	biospider
Osmitrol	db_source
OSMITROL 10% IN WATER	biospider
OSMITROL 10% IN WATER IN PLASTIC CONTAINER	biospider
OSMITROL 15% IN WATER	biospider
OSMITROL 15% IN WATER IN PLASTIC CONTAINER	biospider
OSMITROL 20% IN WATER	biospider
OSMITROL 20% IN WATER IN PLASTIC CONTAINER	biospider
OSMITROL 5% IN WATER	biospider
OSMITROL 5% IN WATER IN PLASTIC CONTAINER	biospider
Osmofundin	biospider
Osmosal	HMDB
Resectisol	db_source
Resectisol in plastic container	biospider
SDM No. 35	biospider
Sorbitol-mannitol	biospider
Sorbitol-mannitol in plastic container	biospider

Chemical Formula

C6H14O6

IUPAC name

hexane-1,2,3,4,5,6-hexol

InChI Identifier

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2

InChI Key

FBPFZTCFMRRESA-UHFFFAOYSA-N

Isomeric SMILES

OCC(O)C(O)C(O)C(O)CO

Average Molecular Weight

182.1718

Monoisotopic Molecular Weight

182.07903818

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Sugar alcohols

Alternative Parents

Substituents

Sugar alcohol
Monosaccharide
Secondary alcohol
Polyol
Hydrocarbon derivative
Primary alcohol
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

a sugar alcohol (SORBITOL )

Physico-Chemical Properties - Experimental

Property	Value	Reference
Experimental logP	-3.10	HANSCH,C ET AL. (1995)
Experimental Water Solubility	216 mg/mL at 25 oC	YALKOWSKY,SH & DANNENFELSER,RM (1992)
Melting Point	Mp 166°	DFC

Foods of Origin