Record Information |
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Version | 1.0 |
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Creation date | 2015-10-09 22:29:42 UTC |
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Update date | 2017-01-19 02:36:19 UTC |
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FoodComEx ID | PC000296 |
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FoodDB Record | FDB022623 |
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Chemical Information |
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Name | dGTP |
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Description | Under normal physiologic conditions, deoxyguanosine (dGuo) undergoes phosphorolysis by purine nucleoside phosphorylase (PNP, EC 2.4.2.1, an enzyme involved in the recycling of nucleosides and deoxynucleosides in cellular remodeling). However, when PNP is inhibited, deoxycytidine kinase (dCK, EC 2.7.1.74) shunts unmetabolized dGuo into deoxyguanosine triphosphate (dGTP), which accumulates and blocks DNA synthesis. Deficiency of purine nucleoside phosphorylase results in defective T-cell immunity. A correlation between the degree of T cell inhibition and the level of dCK activity is observed. (PMID: 11287638, 402573) [HMDB]. dGTP is found in many foods, some of which are jew's ear, evergreen huckleberry, cumin, and red algae. |
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CAS Number | 2564-35-4 |
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Structure | |
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Synonyms | Synonym | Source |
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2'-Deoxyguanosine 5'-triate | ChEBI | 2'-Deoxyguanosine 5'-triic acid | Generator | 2'-Deoxyguanosine 5'-triphosphate | hmdb | 2'-Deoxyguanosine triate | HMDB | 2'-Deoxyguanosine triphosphate | hmdb | Deoxyguanosine 5'-triate | ChEBI | Deoxyguanosine 5'-triic acid | Generator | Deoxyguanosine 5'-triphosphate | hmdb | Deoxyguanosine triate | ChEBI | Deoxyguanosine triic acid | Generator | Deoxyguanosine triphosphate | hmdb |
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Chemical Formula | C10H16N5O13P3 |
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IUPAC name | ({[({[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid |
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InChI Identifier | InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 |
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InChI Key | HAAZLUGHYHWQIW-KVQBGUIXSA-N |
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Isomeric SMILES | NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1 |
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Average Molecular Weight | 507.181 |
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Monoisotopic Molecular Weight | 506.995745159 |
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Chemical Taxonomy |
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Classification | Not classified |
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Physico-Chemical Properties - Experimental |
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Property | Value | Reference |
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Experimental logP | Not Available | |
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Experimental Water Solubility | Not Available | |
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Melting Point | Not Available | |
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Foods of Origin |
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Food | Content Range | Average | Reference |
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Food | | | Reference |
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Production Data |
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Production Method | commercial |
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Production Method Reference | Not Available |
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Production Method Reference File | Not Available |
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Quantity Available | Production upon request, up to 30 mg |
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Delivery Time | Not Available |
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Storage Form | solid |
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Storage Conditions | -80°C |
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Stability | Not Available |
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Purity | Not Available |
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Spectra |
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Spectral Data Upon Request | Not Available |
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Provider Information |
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Commercial Vendors |
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Not Available |