Record Information
Version1.0
Creation date2015-10-09 22:29:17 UTC
Update date2017-01-19 02:36:17 UTC
FoodComEx IDPC000218
FoodDB RecordFDB021888
Chemical Information
NameCortisol
DescriptionCortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis.; Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress. It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep.; Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation. [HMDB]
CAS Number50-23-7
Structure
Thumb
Synonyms
SynonymSource
11-beta-Hydrocortisonehmdb
11-beta-Hydroxycortisonehmdb
11-Hydrocortisonehmdb
11a-Hydroxycorticosteronehmdb
11alpha-Hydroxycorticosteronehmdb
11b-Hydrocortisonehmdb
11b-Hydroxycortisonehmdb
11b,17,21-Trihydroxyprogesteronehmdb
11beta-Hydrocortisonehmdb
11beta-Hydroxycortisonehmdb
11beta,17,21-Trihydroxyprogesteronehmdb
17-Hydroxycorticosteronehmdb
17a-Hydroxycorticosteronehmdb
17alpha-Hydroxycorticosteronehmdb
4-Pregnene-11alpha,21-triol 3,20-dionehmdb
4-Pregnene-11b,17a,21-triol-3,20-dionehmdb
Acticorthmdb
Aeroseb HChmdb
Aeroseb-HChmdb
Ala-Corthmdb
Ala-Scalphmdb
Alacorthmdb
Algicirtishmdb
alphadermhmdb
Amberinhmdb
Anflamhmdb
Anti-inflammatory hormonehmdb
Aquacorthmdb
Aquanil HChmdb
Barseb HChmdb
Basan-Cortihmdb
CaldeCORT Sprayhmdb
Cetacorthmdb
Chronocorthmdb
Clear aidhmdb
Cleitonhmdb
Cobadexhmdb
Compound Fhmdb
Cor-Tar-Quinhmdb
Cort-Domehmdb
Cort-Quinhmdb
Cortanalhmdb
Cortenemahmdb
Cortesalhmdb
Corticremehmdb
Cortifanhmdb
Cortifoamhmdb
Cortimenthmdb
Cortisol alcoholhmdb
Cortisolonumhmdb
Cortisporinhmdb
Cortisporin Oticohmdb
Cortisprayhmdb
Cortizolhmdb
Cortolotionhmdb
Cortonemahmdb
Cortoxidehmdb
Cremesonehmdb
Cremicort-Hhmdb
Cutisolhmdb
Delacorthmdb
Derm-Aidhmdb
Dermilhmdb
Dermolatehmdb
Dihydrocostisonehmdb
Diodermhmdb
Dome-corthmdb
Domolene-HChmdb
Drotichmdb
Ef corlinhmdb
Efcorbinhmdb
Efcortelanhmdb
Efcortelinhmdb
Eldercorthmdb
Epicorthmdb
Epiderm Hhmdb
Esiderm Hhmdb
Evacorthmdb
Ficortrilhmdb
Fiocortrilhmdb
Foille Insettihmdb
Genacorthmdb
Gyno-Cortisonehmdb
H-Corthmdb
HChmdb
Heb Corthmdb
Heb-Corthmdb
Hidalonehmdb
Hidro-Colisonahmdb
Hidrocortisonahmdb
Hycorthmdb
Hycortolhmdb
Hycortolehmdb
Hydracorthmdb
Hydrassonhmdb
Hydro-Adresonhmdb
Hydro-colisonahmdb
Hydrocorthmdb
Hydrocortalhmdb
Hydrocorticosteronehmdb
Hydrocortisonehmdb
Hydrocortisone alcoholhmdb
Hydrocortisone basehmdb
Hydrocortisone free alcoholhmdb
Hydrocortisonumhmdb
Hydrocortistabhmdb
Hydrocortisylhmdb
Hydrocortonehmdb
Hydroskinhmdb
Hydroxycortisonehmdb
Hysonehmdb
Hytisonehmdb
Hytonehmdb
Hytone lotionhmdb
Idrocortisonehmdb
Incortin-Hhmdb
Incortin-hydrogenhmdb
Kendall's compound Fhmdb
Komed HChmdb
Kyypakkaushmdb
Lacticare HChmdb
Lacticare-HChmdb
Lactisonahmdb
Lubricorthmdb
Maintasonehmdb
Medicorthmdb
Meusicorthmdb
Mildisonhmdb
Millidermhmdb
Neo-Cort-Domehmdb
Neosporin-H Earhmdb
Nutracorthmdb
Nystaform-HChmdb
Optefhmdb
Otalginehmdb
Otic-Neo-Cort-Domehmdb
Otobiotichmdb
Otocorthmdb
Otosone-Fhmdb
Pediotic Suspensionhmdb
Penecorthmdb
Permicorthmdb
Polcort Hhmdb
Preparation H Hydrocortisone Creamhmdb
Prepcorthmdb
Prestwick_265hmdb
Prevex HChmdb
Proctocorthmdb
Proctofoamhmdb
Protocorthmdb
Racethmdb
Rectoidhmdb
Reichstein's substance Mhmdb
Remederm HChmdb
Sanatisonhmdb
Scalpicin Capilarhmdb
Schericurhmdb
Scheroson Fhmdb
Sigmacorthmdb
Signefhmdb
Stiefcorcilhmdb
Synacorthmdb
Systral Hydrocorthmdb
Tarcortinhmdb
Timocorthmdb
Topicorthmdb
Transderma Hhmdb
Traumaidehmdb
Unidermhmdb
Vioform-Hydrocortisonehmdb
VoSol HChmdb
Vytonehmdb
Zenoxonehmdb
Chemical FormulaC21H30O5
IUPAC name(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
InChI IdentifierInChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21+/m0/s1
InChI KeyJYGXADMDTFJGBT-CZFMHFDVSA-N
Isomeric SMILES[H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Average Molecular Weight362.4599
Monoisotopic Molecular Weight362.20932407
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 21-hydroxysteroid
  • 20-oxosteroid
  • Pregnane-skeleton
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • Oxosteroid
  • 11-beta-hydroxysteroid
  • 11-hydroxysteroid
  • 17-hydroxysteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Cyclic alcohol
  • Tertiary alcohol
  • Alpha-hydroxy ketone
  • Secondary alcohol
  • Ketone
  • Cyclic ketone
  • Primary alcohol
  • Alcohol
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Hydrocarbon derivative
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External DescriptorsNot Available
Physico-Chemical Properties - Experimental
PropertyValueReference
Experimental logPNot Available
Experimental Water SolubilityNot Available
Melting PointNot Available
Foods of Origin
FoodContent Range AverageReference
FoodReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 2 g
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectra
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez Fresnovazquezf@ualberta.ca
Commercial Vendors
AKSci C481
AKSci J10114
AKSci J40119
AKSci J92891
Cayman Chemical 20739
Glentham GP8860
MetaSci HMDB0014879
Sigma-Aldrich HMDB0014879
Toronto Research Chemicals H714615