Record Information
Version1.0
Creation date2015-10-09 22:29:13 UTC
Update date2017-01-19 02:36:16 UTC
FoodComEx IDPC000209
FoodDB RecordFDB021902
Chemical Information
NameInosine triphosphate
DescriptionInosine triphosphate (ITP) is an intermediate in the purine metabolism pathway. Relatively high levels of ITP in red cells are found in individuals as result of deficiency of inosine triphosphatase (EC 3.1.3.56, ITPase) ITPase is a cytosolic nucleoside triphosphate pyrophosphohydrolase specific for ITP catalysis to inosine monophosphate (IMP) and deoxy-inosine triphosphate (dITP) to deoxy-inosine monophosphate. ITPase deficiency is not associated with any defined pathology other than the characteristic and abnormal accumulation of ITP in red blood cells. Nevertheless, ITPase deficiency may have pharmacogenomic implications, and the abnormal metabolism of 6-mercaptopurine in ITPase-deficient patients may lead to thiopurine drug toxicity. ITPase's function is not clearly understood but possible roles for ITPase could be to prevent the accumulation of rogue nucleotides which would be otherwise incorporated into DNA and RNA, or compete with nucleotides such as GTP in signalling processes. (PMID : 170291, 1204209, 17113761, 17924837) [HMDB]
CAS Number132-06-9
Structure
Thumb
Synonyms
SynonymSource
2'-Inosine-5'-triateChEBI
2'-Inosine-5'-triic acidGenerator
2'-inosine-5'-triphosphatehmdb
5-ITPhmdb
5'-ITPhmdb
Inosine 5hmdb
Inosine 5-triphopshatehmdb
Inosine 5'-(tetrahydrogen triate)HMDB
inosine 5'-(tetrahydrogen triphosphate)hmdb
Inosine 5'-triateChEBI
Inosine 5'-triic acidGenerator
Inosine 5'-triphosphatehmdb
Inosine 5(tetrahydrogen triate)HMDB
Inosine 5(tetrahydrogen triphosphate)hmdb
Inosine triateChEBI
Inosine triic acidGenerator
Inosine triphosphatehmdb
Inosine triphosphic acidhmdb
Inosine tripolyateChEBI
Inosine tripolyic acidGenerator
Inosine tripolyphosphatehmdb
ITPhmdb
ITThmdb
O(5')-(Tetrahydroxytrioryl)inosineChEBI
Chemical FormulaC10H15N4O14P3
IUPAC name({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
InChI IdentifierInChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI KeyHAEJPQIATWHALX-KQYNXXCUSA-N
Isomeric SMILESO[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CN=C2O
Average Molecular Weight508.1658
Monoisotopic Molecular Weight507.979760744
Chemical Taxonomy
ClassificationNot classified
Physico-Chemical Properties - Experimental
PropertyValueReference
Experimental logPNot Available
Experimental Water SolubilityNot Available
Melting PointNot Available
Foods of Origin
FoodContent Range AverageReference
FoodReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 2 g
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectra
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez Fresnovazquezf@ualberta.ca
Commercial Vendors
Not Available