Record Information
Creation date2015-10-09 22:28:06 UTC
Update date2017-01-19 02:36:12 UTC
FoodComEx IDPC000084
FoodDB RecordFDB012567
Chemical Information
NameL-Aspartic acid
DescriptionAspartic acid (Asp, D), also known as aspartate, the name of its anion, is one of the 20 natural proteinogenic amino acids which are the building blocks of proteins. As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong. Aspartic acid is a nonessential amino acid, since it can be made from glutamic acid by enzymes using vitamin B6. The amino acid has important roles in the urea cycle and DNA metabolism. Aspartic acid is a major excitatory neurotransmitter, which is sometimes found to be increased in epileptic and stroke patients. It is decreased in depressed patients and in patients with brain atrophy. Aspartic acid supplements are being evaluated. Five grams can raise blood levels. Magnesium and zinc may be natural inhibitors of some of the actions of aspartic acid. Aspartic acid, with the amino acid phenylalanine, is a part of the natural sweetener, aspartame. This sweetener is an advance in artificial sweeteners and is probably safe in normal doses to all except phenylketonurics. The jury is still out on the long-term effects it has on many brain neurohormones. Aspartic acid may be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Many claims have been made for the special value of administering aspartic acid in the form of potassium and magnesium salts. Since aspartic acid is relatively nontoxic, studies are now in progress to elucidate its pharmacological and therapeutic roles.
CAS Number56-84-8
(+)-Aspartic acidbiospider
(2S)-2-Aminobutanedioic acidbiospider
(2S)-Aspartic acidbiospider
(L)-Aspartic acidbiospider
(S)-(+)-Aminosuccinic acidbiospider
(S)-(+)-Aspartic acidbiospider
(S)-2-Aminobutanedioic acidbiospider
(S)-2-Aminosuccinic acidbiospider
(S)-amino-Butanedioic acidHMDB
(S)-Aminobutanedioic acidbiospider
(S)-Aspartic acidbiospider
2-amino-3-Methylsuccinic acidHMDB
2-Aminosuccinic acidChEBI
alpha-Aminosuccinic acidHMDB
Asparagic acidHMDB
Asparaginic acidHMDB
Aspartic acid, INN, USAN; L-formdb_source
Aspartic acid, L- (8CI)biospider
FEMA 3656db_source
L-(+)-Aspartic acidbiospider
L-2-Aminobutanedioic acidbiospider
L-Aminosuccinic acidbiospider
L-Asparagic acidbiospider
L-Asparaginic acidbiospider
L-Aspartic acid (9CI)biospider
Chemical FormulaC4H7NO4
IUPAC name(2S)-2-aminobutanedioic acid
InChI IdentifierInChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
Isomeric SMILESN[C@@H](CC(O)=O)C(O)=O
Average Molecular Weight133.1027
Monoisotopic Molecular Weight133.037507717
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAspartic acid and derivatives
Alternative Parents
  • Aspartic acid or derivatives
  • Alpha-amino acid
  • L-alpha-amino acid
  • Dicarboxylic acid or derivatives
  • Fatty acid
  • Amino acid
  • Carboxylic acid
  • Organic oxide
  • Organopnictogen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organic oxygen compound
  • Carbonyl group
  • Amine
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physico-Chemical Properties - Experimental
Experimental logP-3.89CHMELIK,J ET AL. (1991)
Experimental Water Solubility5.36 mg/mL at 25 oCYALKOWSKY,SH & HE,Y (2003)
Melting PointMp 269-271° dec.DFC
Foods of Origin
FoodContent Range AverageReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 7 g
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez
Commercial Vendors
AKSci G144
Alfa Aesar HMDB0000191
Glentham GM3196
Glentham GM0348
MetaSci HMDB0000191
Toronto Research Chemicals A790024