Record Information
Creation date2015-10-09 22:28:04 UTC
Update date2017-01-19 02:36:12 UTC
FoodComEx IDPC000082
FoodDB RecordFDB000522
Chemical Information
DescriptionPresent in germinating peas, Jack bean seeds (Canavalia ensiformis) and the seedlings of many leguminous plants Homoserine is a more reactive variant of the amino acid serine. In this variant, the hydroxyl side chain contains an additional CH2 group which brings the hydroxyl group closer to its own carboxyl group, allowing it to chemically react to form a five-membered ring. This occurs at the point that amino acids normally join to their neighbours in a peptide bond.; Homoserine is therefore unsuitable for forming proteins and has been eliminated from the repertoire of amino acids used by living things.; Homoserine is the final product on the C-terminal end of the N-terminal fragment following a cyanogen bromide cleavage. (wikipedia); Homoserine is an intermediate in the biosynthesis of three essential amino acids: methionine, threonine (an isomer of homoserine), and isoleucine. It forms by two reductions of aspartic acid via the intermediacy of aspartate semialdehyde.; Homoserine is an ?-amino acid with the chemical formula HO2CCH(NH2)CH2CH2OH. L-Homoserine is not one of the common amino acids encoded by DNA. It differs from the proteinogenic amino acid serine by insertion of an additional methylene group. Homoserine, or its lactone form, is the product of a cyanogen bromide cleavage of a peptide by degradation of methionine. L-Homoserine is found in many foods, some of which are cornmint, star fruit, common wheat, and nance.
CAS Number672-15-1
(2S)-2-amino-4-hydroxybutanoic acidbiospider
(S)-2-amino-4-hydroxy-Butanoic acidbiospider
(S)-2-Amino-4-hydroxybutanoic acidbiospider
(S)-2-Amino-4-hydroxybutyric acidbiospider
2-amino-4-hydroxy-Butyric acidbiospider
2-amino-4-hydroxy-L-Butyric acidbiospider
2-Amino-4-hydroxybutanoic acidbiospider
2-Amino-4-hydroxybutanoic acid; L-formdb_source
2-Amino-4-hydroxybutyric acidbiospider
Butanoic acid, 2-amino-4-hydroxy-, (S)-biospider
Butyric acid, 2-amino-4-hydroxy-, L-biospider
Butyric acid, 2-amino-4-hydroxy-, L- (8CI)biospider
Homoserine (van)biospider
Chemical FormulaC4H9NO3
IUPAC name2-amino-4-hydroxybutanoic acid
InChI IdentifierInChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)
Average Molecular Weight119.1192
Monoisotopic Molecular Weight119.058243159
Chemical Taxonomy
Description Belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acids
Alternative Parents
  • Alpha-amino acid
  • Short-chain hydroxy acid
  • Fatty acid
  • 1,3-aminoalcohol
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Primary aliphatic amine
  • Organopnictogen compound
  • Carbonyl group
  • Amine
  • Organic oxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physico-Chemical Properties - Experimental
Experimental logPNot Available
Experimental Water Solubility1000 mg/mL at 30 oCBEILSTEIN
Melting PointMp 203° dec.DFC
Foods of Origin
FoodContent Range AverageReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 6 g
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez
Commercial Vendors
AKSci J90653
AKSci K105
Alfa Aesar HMDB0000719
MetaSci HMDB0000719
Toronto Research Chemicals H615010