Record Information
Creation date2015-10-09 22:28:01 UTC
Update date2017-01-19 02:36:12 UTC
FoodComEx IDPC000075
FoodDB RecordFDB022083
Chemical Information
DescriptionD-Arabitol or D-arabinitol, also known as klinit or lyxitol, belongs to the class of organic compounds known as sugar alcohols, a type of polyols. These are hydrogenated forms of carbohydrates in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group. A polyol is an organic compound containing many hydroxyls. D-Arabitol is neutral compound. Polyols, classified by the number of carbon atoms and include the sugar alcohols, are linked to the pentose phosphate pathway (PPP). The PPP generates, NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, a precursor for the synthesis of nucleotides. While the pentose phosphate pathway oxidizes glucose, its primary role is anabolic rather than catabolic. Polyols, including D-arabitol, accumulates in body fluids in individuals with two defects in PPP, involving the enzymes ribose-5-phosphate isomerase (RPI) and transaldolase (PMID: 18987987). A patient with leukoencephalopathy and peripheral neuropathy, with a strong brain-CSF-plasma gradient of C5 polyols such as D-arabitol, was identified as suffering from RPI deficiency. Another patient displaying mainly liver problems and increased concentrations of polyols, mainly D-arabitol, was diagnosed with transaldolase deficiency. However, the mechanism of pathophysiology of polyols in patients with defects in the PPP is poorly understood. It is thought that D-arabitol is a metabolic end-product in humans. The mechanisms of brain and neuronal damage in RPI deficiency may result from polyol accumulation, causing secondary brain dysfunction (PMID: 16435225). D-Arabitol is a product of the enzyme D-arabinitol 4-dehydrogenase (EC in the pentose and glucuronate interconversion pathway. D-Arabitol accumulated in a Penicillium rubens strain deleted of four highly expressed biosynthetic gene clusters that produce penicillin, roquefortine, chrysogine and fungisporin. The transcriptome of the P. rubens strain had changed when the gene cluster was removed, resulting in increased expression of D-arabinitol 4-dehydrogenase (PMID: 32376967). D-Arabitol, a fungal metabolite, is used as a marker for invasive candidiasis or infection by Candida fungal species (PMID: 15183861; PMID: 10647119). It is also a metabolite of Debaryomyces, Pichia and Zygosaccharomyces (PMID: 25809659).
CAS Number488-81-3
Chemical FormulaC5H12O5
IUPAC name(2R,3s,4S)-pentane-1,2,3,4,5-pentol
InChI IdentifierInChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5-
Isomeric SMILESOC[C@H](O)[C@H](O)[C@H](O)CO
Average Molecular Weight152.1458
Monoisotopic Molecular Weight152.068473494
Chemical Taxonomy
Description Belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentSugar alcohols
Alternative Parents
  • Sugar alcohol
  • Monosaccharide
  • Secondary alcohol
  • Polyol
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physico-Chemical Properties - Experimental
Experimental logPNot Available
Experimental Water SolubilityNot Available
Melting PointNot Available
Foods of Origin
FoodContent Range AverageReference
Production Data
Production Methodcommercial
Production Method ReferenceNot Available
Production Method Reference FileNot Available
Quantity AvailableProduction upon request, up to 2 g
Delivery TimeNot Available
Storage Formsolid
Storage Conditions-80°C
StabilityNot Available
PurityNot Available
Spectral Data Upon RequestNot Available
Provider Information
Contact NameContact InstitutionContact Email
Rosa Vazquez
Commercial Vendors
AKSci C452
Glentham GC5301
MetaSci HMDB0000508
Tokyo Chemical Industry HMDB0000508