FComEx: 3-Methoxytyrosine (PC000945)

Record Information

Version

1.0

Creation date

2015-10-09 22:33:32 UTC

Update date

2017-01-19 02:36:42 UTC

FoodComEx ID

PC000945

FoodDB Record

FDB022620

Chemical Information

Name

3-Methoxytyrosine

Description

3-Methoxytyrosine is one of the main biochemical markers for Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) deficiency, an inborn error of metabolism that affects serotonin and dopamine biosynthesis. Patients are usually detected in infancy due to developmental delay, hypotonia, and extrapyramidal movements. Diagnosis is based on an abnormal neurotransmitter metabolite profile in CSF and reduced AADC activity in plasma. 3-methoxytyrosine is elevated in CSF, plasma, and urine. (PMID 1357595, 1281049, 16288991) [HMDB]

CAS Number

7636-26-2

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
3-methoxy-tyrosine	hmdb
3-methoxytyrosine	hmdb
3-O-Methyldopa	hmdb
l-3-Methoxy tyrosine	hmdb
L-3-Methoxytyrosine	hmdb
L-4-Hydroxy-3-methoxyphenylalanine	hmdb
vanilalanine	hmdb

Chemical Formula

C10H13NO4

IUPAC name

2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid

InChI Identifier

InChI=1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)

InChI Key

PFDUUKDQEHURQC-UHFFFAOYSA-N

Isomeric SMILES

COC1=C(O)C=CC(CC(N)C(O)=O)=C1

Average Molecular Weight

211.2145

Monoisotopic Molecular Weight

211.084457909

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Tyrosine and derivatives

Alternative Parents